Studies on leptospiral vaccine

Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates

Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by pathogenic Leptospira spp. that can infect a wide range of domestic and wild animals. Given the inability to control the cycle of transmission amon...

Leptospiral Pathogenomics

Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide. Research on the mechanisms of Leptospira pathogenesis has been hindered due to slow growth of infectious strains, poor transformability, and a paucity of genetic tools. As a result of second generation sequencing technologies, there has be...

Leptospiral Uveitis.

Leptospirosis is widely regarded as the most widespread zoonosis in the world. Systemic leptospirosis is a biphasic illness. Ocular involvement in leptospirosis has been reported to be extremely variable, ranging from 2% to 90%. Ocular involvement is seen both in the systemic bacteraemic phase as well as in the immunological phase. Leptospiral uveitis is a common entity in the tropical countrie...

Studies on influenza vaccine in industry.

Large scale studies of influenza vaccination in industry have recently been started. The studies are of two types: (a) Vaccination was offered to a factory and a record maintained of sickness absence of all employees, both the vaccinated volunteers and the nonvolunteers. In five different factories, the average acceptance rate was 42%. An analysis of the volunteers in one factory indicated that...

Further Observations on Leptospiral Infections in Calcutta